Personalized Therapeutics: HIV Treatment in Adolescents

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Polymer therapeutics (PTs) provides a potentially exciting approach for the treatment of many diseases by enhancing aqueous solubility and altering drug pharmacokinetics at both the whole organism and subcellular level leading to improved therapeutic outcomes. However, the failure of many polymer-drug conjugates in clinical trials suggests that we may need to stratify patients in order to match...

Pharmacogenomics and HIV therapeutics.

AIDS offers perhaps the greatest threat to humans by any infectious disease in history. In response to this challenge, at least 19 distinct antiretroviral agents that target HIV reverse transcriptase, protease, or viral entry have been approved for clinical use. Such a broad armamentarium is critical , given the nature of antiretroviral therapy , which requires the lifelong administration of mu...

Personalized therapeutics and companion diagnostics: a new paradigm in testing and treatment.

Serum contains 1-transferrin, and CSF contains 1 and 2 transferrins. The 2-transferrin in CSF is desialylated because of the presence of neuraminidase in the central nervous system. Hence, 2-transferrin is used as a marker of CSF leakage (1 ). Because 1-transferrin was present in serum but absent in drainage fluid, additional neuraminidase activity was suspected. This suspicion was supported by...

Fragment screening and HIV therapeutics.

Fragment screening has proven to be a powerful alternative to traditional methods for drug discovery. Biophysical methods, such as X-ray crystallography, NMR spectroscopy, and surface plasmon resonance, are used to screen a diverse library of small molecule compounds. Although compounds identified via this approach have relatively weak affinity, they provide a good platform for lead development...

Art, Science, and Personalized Cancer Care Through Regional Therapeutics.